Acellular Allograft Amniotic Membrane

aril® is a room temperature stable allograft derived from human placental tissue collected from consenting donors. Post-decellularization & stabilization, aril® is packaged in a double pouch packaging system and subjected to low-dose gamma irradiation. aril® is an allograft tissue intended for homologous use regulated by 21 CFR Part 1271 and Section 361 of the PHS Act.

aril® is configured as a precision-cut single layer of amnion shaped as an ellipse or disc. The configuration was selected and designed to maximize clinically usable surface area and limit necessary pre-operative manipulation of the graft. Seed Biotech, Inc. has shown a greater than 95% reduction in DNA using their proprietary decellularization process. [2] As a single layer of amnion, it is not necessary to emboss aril® as there is no side-specific orientation to the graft.  

Design and Handling

aril® is an acellular, precision-cut graft, designed and produced under industry-expert guidance for consistency, reliable handling, and clinical practicality.

Homologous Use

Amniotic membrane has a long, well-documented history of use as a covering and protective barrier across ophthalmic, surgical, and wound-covering settings. As a single-layer amnion allograft, aril® serves in its native function: covering the site, providing a protective biologic barrier, and acting as a scaffold. Seed Biotech® combines the natural structure of amniotic membrane with its proprietary processing to produce a consistent, acellular allograft, handled to established tissue-industry standards.  

Processing Defines What Remains

Amniotic membrane allografts are not processed the same way, and the method determines what stays in the graft. Grafts preserved by cryopreservation or chemical cross-linking retain donor cells and genetic material, and some processes introduce residual agents. aril® takes a different path: decellularization. Cells, intracellular DNA, and antigens are removed while the extracellular matrix and basement membrane are preserved.

aril® is processed to greater than 95% donor DNA reduction, with residual DNA quantified lot-to-lot against defined release criteria. We report the characterization and leave the clinical judgment to the treating physician.

Available Configurations